Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study.
Identifieur interne : 000E76 ( Main/Exploration ); précédent : 000E75; suivant : 000E77Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study.
Auteurs : G V Long [Australie] ; K T Flaherty [États-Unis] ; D. Stroyakovskiy [Russie] ; H. Gogas [Grèce] ; E. Levchenko [Russie] ; F. De Braud [Italie] ; J. Larkin [Royaume-Uni] ; C. Garbe [Allemagne] ; T. Jouary [France] ; A. Hauschild [Allemagne] ; V. Chiarion-Sileni [Italie] ; C. Lebbe [France] ; M. Mandalà [Italie] ; M. Millward [Australie] ; A. Arance [Espagne] ; I. Bondarenko [Ukraine] ; J B A G. Haanen [Pays-Bas] ; J. Hansson [Suède] ; J. Utikal [Allemagne] ; V. Ferraresi [Italie] ; P. Mohr [Allemagne] ; V. Probachai [Ukraine] ; D. Schadendorf [Allemagne] ; P. Nathan [Royaume-Uni] ; C. Robert [France] ; A. Ribas [États-Unis] ; M A Davies [États-Unis] ; S R Lane [États-Unis] ; J J Legos [États-Unis] ; B. Mookerjee [États-Unis] ; J-J Grob [France]Source :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2017.
Abstract
Previous analysis of COMBI-d (NCT01584648) demonstrated improved progression-free survival (PFS) and overall survival (OS) with combination dabrafenib and trametinib versus dabrafenib monotherapy in BRAF V600E/K-mutant metastatic melanoma. This study was continued to assess 3-year landmark efficacy and safety after ≥36-month follow-up for all living patients.
DOI: 10.1093/annonc/mdx176
PubMed: 28475671
Affiliations:
- Allemagne, Australie, Espagne, France, Grèce, Italie, Pays-Bas, Royaume-Uni, Russie, Suède, Ukraine, États-Unis
- Angleterre, Aquitaine, Attique (région), Bade-Wurtemberg, Californie, Catalogne, District de Tübingen, District fédéral central, Grand Londres, Hollande-Septentrionale, Latium, Lombardie, Massachusetts, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur, Schleswig-Holstein, Svealand, Texas, Île-de-France
- Amsterdam, Athènes, Barcelone, Boston, Houston, Kiel, Londres, Los Angeles, Marseille, Milan, Moscou, Orsay, Paris, Pau, Rome, Stockholm, Sydney, Tübingen
- Université Paris-Sud, Université de Sydney
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Utikal</name><affiliation wicri:level="1"><nlm:affiliation>Skin Cancer Unit, German Cancer Research Center (DKFZ) and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls University of Heidelberg, Mannheim and Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Skin Cancer Unit, German Cancer Research Center (DKFZ) and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls University of Heidelberg, Mannheim and Heidelberg</wicri:regionArea><wicri:noRegion>Mannheim and Heidelberg</wicri:noRegion><wicri:noRegion>Mannheim and Heidelberg</wicri:noRegion><wicri:noRegion>Mannheim and Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Ferraresi, V" sort="Ferraresi, V" uniqKey="Ferraresi V" first="V" last="Ferraresi">V. 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Robert</name><affiliation wicri:level="4"><nlm:affiliation>Gustave Roussy, Département de Médecine Oncologique, Service de Dermatologie et Université Paris-Sud, Faculté de Médecine, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, Département de Médecine Oncologique, Service de Dermatologie et Université Paris-Sud, Faculté de Médecine, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Ribas, A" sort="Ribas, A" uniqKey="Ribas A" first="A" last="Ribas">A. Ribas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Hematology/Oncology, UCLA Jonsson Comprehensive Cancer Center, Los Angeles, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Hematology/Oncology, UCLA Jonsson Comprehensive Cancer Center, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Davies, M A" sort="Davies, M A" uniqKey="Davies M" first="M A" last="Davies">M A Davies</name><affiliation wicri:level="3"><nlm:affiliation>Melanoma Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Melanoma Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, Houston</wicri:regionArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Lane, S R" sort="Lane, S R" uniqKey="Lane S" first="S R" last="Lane">S R Lane</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:regionArea><wicri:noRegion>East Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Legos, J J" sort="Legos, J J" uniqKey="Legos J" first="J J" last="Legos">J J Legos</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:regionArea><wicri:noRegion>East Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Mookerjee, B" sort="Mookerjee, B" uniqKey="Mookerjee B" first="B" last="Mookerjee">B. 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Stroyakovskiy</name><affiliation wicri:level="3"><nlm:affiliation>Moscow City Oncology Hospital #62, Moscow, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Moscow City Oncology Hospital #62, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Gogas, H" sort="Gogas, H" uniqKey="Gogas H" first="H" last="Gogas">H. Gogas</name><affiliation wicri:level="3"><nlm:affiliation>First Department of Medicine, "Laiko" General Hospital, National and Kapodistrian University of Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Medicine, "Laiko" General Hospital, National and Kapodistrian University of Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Levchenko, E" sort="Levchenko, E" uniqKey="Levchenko E" first="E" last="Levchenko">E. Levchenko</name><affiliation wicri:level="1"><nlm:affiliation>Petrov Research Institute of Oncology, Saint Petersburg, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Petrov Research Institute of Oncology, Saint Petersburg</wicri:regionArea><wicri:noRegion>Saint Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="De Braud, F" sort="De Braud, F" uniqKey="De Braud F" first="F" last="De Braud">F. De Braud</name><affiliation wicri:level="3"><nlm:affiliation>Dipartimento di Medicina Oncologica, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Oncologica, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Larkin, J" sort="Larkin, J" uniqKey="Larkin J" first="J" last="Larkin">J. Larkin</name><affiliation wicri:level="3"><nlm:affiliation>Royal Marsden NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Garbe, C" sort="Garbe, C" uniqKey="Garbe C" first="C" last="Garbe">C. Garbe</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University of Tübingen, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University of Tübingen, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Jouary, T" sort="Jouary, T" uniqKey="Jouary T" first="T" last="Jouary">T. Jouary</name><affiliation wicri:level="3"><nlm:affiliation>Service D'oncologie Médicale, Hopital Francois Mitterrand, Pau, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service D'oncologie Médicale, Hopital Francois Mitterrand, Pau</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Pau</settlement></placeName></affiliation></author><author><name sortKey="Hauschild, A" sort="Hauschild, A" uniqKey="Hauschild A" first="A" last="Hauschild">A. Hauschild</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Chiarion Sileni, V" sort="Chiarion Sileni, V" uniqKey="Chiarion Sileni V" first="V" last="Chiarion-Sileni">V. Chiarion-Sileni</name><affiliation wicri:level="1"><nlm:affiliation>Melanoma and Oesophageal Oncology Unit, Veneto Oncology Institute-IRCCS, Padova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Melanoma and Oesophageal Oncology Unit, Veneto Oncology Institute-IRCCS, Padova</wicri:regionArea><wicri:noRegion>Padova</wicri:noRegion></affiliation></author><author><name sortKey="Lebbe, C" sort="Lebbe, C" uniqKey="Lebbe C" first="C" last="Lebbe">C. Lebbe</name><affiliation wicri:level="3"><nlm:affiliation>APHP Dermatology and CIC Departments, INSERM U976, University Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHP Dermatology and CIC Departments, INSERM U976, University Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mandala, M" sort="Mandala, M" uniqKey="Mandala M" first="M" last="Mandalà">M. Mandalà</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology and Hematology, Papa Giovanni XXIII Hospital, Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology and Hematology, Papa Giovanni XXIII Hospital, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Millward, M" sort="Millward, M" uniqKey="Millward M" first="M" last="Millward">M. Millward</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, Sir Charles Gairdner Hospital, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Medical Oncology Department, Sir Charles Gairdner Hospital, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Arance, A" sort="Arance, A" uniqKey="Arance A" first="A" last="Arance">A. Arance</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Hospital Clinic of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, Hospital Clinic of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bondarenko, I" sort="Bondarenko, I" uniqKey="Bondarenko I" first="I" last="Bondarenko">I. Bondarenko</name><affiliation wicri:level="1"><nlm:affiliation>Dnipropetrovsk State Medical Academy, Clinical Hospital #4, Dnipropetrovsk, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Dnipropetrovsk State Medical Academy, Clinical Hospital #4, Dnipropetrovsk</wicri:regionArea><wicri:noRegion>Dnipropetrovsk</wicri:noRegion></affiliation></author><author><name sortKey="Haanen, J B A G" sort="Haanen, J B A G" uniqKey="Haanen J" first="J B A G" last="Haanen">J B A G. Haanen</name><affiliation wicri:level="3"><nlm:affiliation>Netherlands Cancer Institute, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Hansson, J" sort="Hansson, J" uniqKey="Hansson J" first="J" last="Hansson">J. Hansson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Utikal, J" sort="Utikal, J" uniqKey="Utikal J" first="J" last="Utikal">J. Utikal</name><affiliation wicri:level="1"><nlm:affiliation>Skin Cancer Unit, German Cancer Research Center (DKFZ) and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls University of Heidelberg, Mannheim and Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Skin Cancer Unit, German Cancer Research Center (DKFZ) and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls University of Heidelberg, Mannheim and Heidelberg</wicri:regionArea><wicri:noRegion>Mannheim and Heidelberg</wicri:noRegion><wicri:noRegion>Mannheim and Heidelberg</wicri:noRegion><wicri:noRegion>Mannheim and Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Ferraresi, V" sort="Ferraresi, V" uniqKey="Ferraresi V" first="V" last="Ferraresi">V. Ferraresi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology A, Regina Elena National Cancer Institute, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Oncology A, Regina Elena National Cancer Institute, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Mohr, P" sort="Mohr, P" uniqKey="Mohr P" first="P" last="Mohr">P. Mohr</name><affiliation wicri:level="1"><nlm:affiliation>Dermatologisches Zentrum Buxtehude, Elbe Kliniken Buxtehude, Buxtehude, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dermatologisches Zentrum Buxtehude, Elbe Kliniken Buxtehude, Buxtehude</wicri:regionArea><wicri:noRegion>Buxtehude</wicri:noRegion><wicri:noRegion>Buxtehude</wicri:noRegion><wicri:noRegion>Buxtehude</wicri:noRegion></affiliation></author><author><name sortKey="Probachai, V" sort="Probachai, V" uniqKey="Probachai V" first="V" last="Probachai">V. Probachai</name><affiliation wicri:level="1"><nlm:affiliation>Dnipropetrovsk Clinical Oncology Center of Dnipropetrovsk State Council, Dnipropetrovsk, Ukraine.</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Dnipropetrovsk Clinical Oncology Center of Dnipropetrovsk State Council, Dnipropetrovsk</wicri:regionArea><wicri:noRegion>Dnipropetrovsk</wicri:noRegion></affiliation></author><author><name sortKey="Schadendorf, D" sort="Schadendorf, D" uniqKey="Schadendorf D" first="D" last="Schadendorf">D. Schadendorf</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, University Hospital Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Nathan, P" sort="Nathan, P" uniqKey="Nathan P" first="P" last="Nathan">P. Nathan</name><affiliation wicri:level="1"><nlm:affiliation>Mount Vernon Cancer Centre, Northwood, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Mount Vernon Cancer Centre, Northwood</wicri:regionArea><wicri:noRegion>Northwood</wicri:noRegion></affiliation></author><author><name sortKey="Robert, C" sort="Robert, C" uniqKey="Robert C" first="C" last="Robert">C. Robert</name><affiliation wicri:level="4"><nlm:affiliation>Gustave Roussy, Département de Médecine Oncologique, Service de Dermatologie et Université Paris-Sud, Faculté de Médecine, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy, Département de Médecine Oncologique, Service de Dermatologie et Université Paris-Sud, Faculté de Médecine, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Ribas, A" sort="Ribas, A" uniqKey="Ribas A" first="A" last="Ribas">A. Ribas</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine, Hematology/Oncology, UCLA Jonsson Comprehensive Cancer Center, Los Angeles, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Hematology/Oncology, UCLA Jonsson Comprehensive Cancer Center, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Davies, M A" sort="Davies, M A" uniqKey="Davies M" first="M A" last="Davies">M A Davies</name><affiliation wicri:level="3"><nlm:affiliation>Melanoma Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Melanoma Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, Houston</wicri:regionArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Lane, S R" sort="Lane, S R" uniqKey="Lane S" first="S R" last="Lane">S R Lane</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:regionArea><wicri:noRegion>East Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Legos, J J" sort="Legos, J J" uniqKey="Legos J" first="J J" last="Legos">J J Legos</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:regionArea><wicri:noRegion>East Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Mookerjee, B" sort="Mookerjee, B" uniqKey="Mookerjee B" first="B" last="Mookerjee">B. Mookerjee</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:regionArea><wicri:noRegion>East Hanover</wicri:noRegion></affiliation></author><author><name sortKey="Grob, J J" sort="Grob, J J" uniqKey="Grob J" first="J-J" last="Grob">J-J Grob</name><affiliation wicri:level="3"><nlm:affiliation>Service de Dermatologie, Centre Hospitalo-Universitaire Timone, Aix-Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Dermatologie, Centre Hospitalo-Universitaire Timone, Aix-Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous analysis of COMBI-d (NCT01584648) demonstrated improved progression-free survival (PFS) and overall survival (OS) with combination dabrafenib and trametinib versus dabrafenib monotherapy in BRAF V600E/K-mutant metastatic melanoma. This study was continued to assess 3-year landmark efficacy and safety after ≥36-month follow-up for all living patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Russie</li><li>Suède</li><li>Ukraine</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Attique (région)</li><li>Bade-Wurtemberg</li><li>Californie</li><li>Catalogne</li><li>District de Tübingen</li><li>District fédéral central</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Latium</li><li>Lombardie</li><li>Massachusetts</li><li>Nouvelle-Aquitaine</li><li>Nouvelle-Galles du Sud</li><li>Provence-Alpes-Côte d'Azur</li><li>Schleswig-Holstein</li><li>Svealand</li><li>Texas</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Athènes</li><li>Barcelone</li><li>Boston</li><li>Houston</li><li>Kiel</li><li>Londres</li><li>Los Angeles</li><li>Marseille</li><li>Milan</li><li>Moscou</li><li>Orsay</li><li>Paris</li><li>Pau</li><li>Rome</li><li>Stockholm</li><li>Sydney</li><li>Tübingen</li></settlement><orgName><li>Université Paris-Sud</li><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Long, G V" sort="Long, G V" uniqKey="Long G" first="G V" last="Long">G V Long</name></region><name sortKey="Millward, M" sort="Millward, M" uniqKey="Millward M" first="M" last="Millward">M. Millward</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Flaherty, K T" sort="Flaherty, K T" uniqKey="Flaherty K" first="K T" last="Flaherty">K T Flaherty</name></region><name sortKey="Davies, M A" sort="Davies, M A" uniqKey="Davies M" first="M A" last="Davies">M A Davies</name><name sortKey="Lane, S R" sort="Lane, S R" uniqKey="Lane S" first="S R" last="Lane">S R Lane</name><name sortKey="Legos, J J" sort="Legos, J J" uniqKey="Legos J" first="J J" last="Legos">J J Legos</name><name sortKey="Mookerjee, B" sort="Mookerjee, B" uniqKey="Mookerjee B" first="B" last="Mookerjee">B. Mookerjee</name><name sortKey="Ribas, A" sort="Ribas, A" uniqKey="Ribas A" first="A" last="Ribas">A. Ribas</name></country><country name="Russie"><region name="District fédéral central"><name sortKey="Stroyakovskiy, D" sort="Stroyakovskiy, D" uniqKey="Stroyakovskiy D" first="D" last="Stroyakovskiy">D. Stroyakovskiy</name></region><name sortKey="Levchenko, E" sort="Levchenko, E" uniqKey="Levchenko E" first="E" last="Levchenko">E. Levchenko</name></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Gogas, H" sort="Gogas, H" uniqKey="Gogas H" first="H" last="Gogas">H. Gogas</name></region></country><country name="Italie"><region name="Lombardie"><name sortKey="De Braud, F" sort="De Braud, F" uniqKey="De Braud F" first="F" last="De Braud">F. De Braud</name></region><name sortKey="Chiarion Sileni, V" sort="Chiarion Sileni, V" uniqKey="Chiarion Sileni V" first="V" last="Chiarion-Sileni">V. Chiarion-Sileni</name><name sortKey="Ferraresi, V" sort="Ferraresi, V" uniqKey="Ferraresi V" first="V" last="Ferraresi">V. Ferraresi</name><name sortKey="Mandala, M" sort="Mandala, M" uniqKey="Mandala M" first="M" last="Mandalà">M. Mandalà</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Larkin, J" sort="Larkin, J" uniqKey="Larkin J" first="J" last="Larkin">J. Larkin</name></region><name sortKey="Nathan, P" sort="Nathan, P" uniqKey="Nathan P" first="P" last="Nathan">P. Nathan</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Garbe, C" sort="Garbe, C" uniqKey="Garbe C" first="C" last="Garbe">C. Garbe</name></region><name sortKey="Hauschild, A" sort="Hauschild, A" uniqKey="Hauschild A" first="A" last="Hauschild">A. Hauschild</name><name sortKey="Mohr, P" sort="Mohr, P" uniqKey="Mohr P" first="P" last="Mohr">P. Mohr</name><name sortKey="Schadendorf, D" sort="Schadendorf, D" uniqKey="Schadendorf D" first="D" last="Schadendorf">D. Schadendorf</name><name sortKey="Utikal, J" sort="Utikal, J" uniqKey="Utikal J" first="J" last="Utikal">J. Utikal</name></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Jouary, T" sort="Jouary, T" uniqKey="Jouary T" first="T" last="Jouary">T. Jouary</name></region><name sortKey="Grob, J J" sort="Grob, J J" uniqKey="Grob J" first="J-J" last="Grob">J-J Grob</name><name sortKey="Lebbe, C" sort="Lebbe, C" uniqKey="Lebbe C" first="C" last="Lebbe">C. Lebbe</name><name sortKey="Robert, C" sort="Robert, C" uniqKey="Robert C" first="C" last="Robert">C. Robert</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Arance, A" sort="Arance, A" uniqKey="Arance A" first="A" last="Arance">A. Arance</name></region></country><country name="Ukraine"><noRegion><name sortKey="Bondarenko, I" sort="Bondarenko, I" uniqKey="Bondarenko I" first="I" last="Bondarenko">I. Bondarenko</name></noRegion><name sortKey="Probachai, V" sort="Probachai, V" uniqKey="Probachai V" first="V" last="Probachai">V. Probachai</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Haanen, J B A G" sort="Haanen, J B A G" uniqKey="Haanen J" first="J B A G" last="Haanen">J B A G. Haanen</name></region></country><country name="Suède"><region name="Svealand"><name sortKey="Hansson, J" sort="Hansson, J" uniqKey="Hansson J" first="J" last="Hansson">J. Hansson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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